An extensive renovation of a former warehouse facility in South Boston’s Marine Industrial Park created a technologically advanced research space for Dana-Farber Cancer Institute. To accommodate the DFCI’s relocation needs and to bring research facilities online as quickly as possible, a four-phased project schedule and detailed site management plan was developed allowing for phased occupancy while ensuring minimal disruption to sensitive research operations. This adaptive reuse strategy introduced state-of-the-art research and support spaces to the building such as BL-2 laboratories, wet laboratories, MRIs, holding areas, cryogenic tissue preservation, materials management, and animal imaging center. The new facility has necessitated new infrastructure, including a new boiler plant and two standby emergency generators.